4-(Dimethylamino)butan-1-ol → 4-(Dimethylamino)butyl 2-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetate

HRID 1617262

반응식

HRID 1617262 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([OH:23])=[O:22])=[CH:16][C:15]=2[OH:24])=[C:4]([CH3:25])[N:3]=1.[CH3:26][N:27]([CH3:33])[CH2:28][CH2:29][CH2:30][CH2:31]O>>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([O:23][CH2:31][CH2:30][CH2:29][CH2:28][N:27]([CH3:33])[CH3:26])=[O:22])=[CH:16][C:15]=2[OH:24])=[C:4]([CH3:25])[N:3]=1

참가 물질

3

반응물 2

HCID 833504-(Dimethylamino)butan-1-olHCID 684141362-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetic acid

생성물 1

HCID 578248444-(Dimethylamino)butyl 2-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetate

실험 절차

The title compound was prepared using product of example 79 step (i) (80 mg) and 4-(dimethylamino)butan-1-ol using the general coupling method of example 74 step (iii). The product was purified by RPHPLC to give the product, 25 mg.

후처리

  1. customThe product was purified by RPHPLC
  2. customto give the product, 25 mg

출처 및 근거

ORD 기록
ord-8cfc86100e3348eb866ce21acd8e6255
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765939B2

연결된 노트

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