4-Iodopyridine → 2-(9H-Fluoren-9-yl)-1-pyridin-4-yl-ethanone

HRID 1617491

반응식

HRID 1617491 반응식
[CH:1]1[C:13]2[CH:12]([CH2:14][C:15](N(OC)C)=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.I[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1.[Li]CCCC>C1COCC1>[CH:1]1[C:13]2[CH:12]([CH2:14][C:15]([C:22]3[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=3)=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 6094924-IodopyridineHCID 866609452-(9H-Fluoren-9-yl)-N-methoxy-N-methyl-acetamideHCID 178418339Butyllithium

생성물 1

HCID 666665732-(9H-Fluoren-9-yl)-1-pyridin-4-yl-ethanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In analogy to example 55, step 2, from 2-(9H-fluoren-9-yl)-N-methoxy-N-methyl-acetamide and 4-iodopyridine using isopropylmagnesium chloride lithium chloride complex in THF at rt (instead of n-BuLi at −70° C.) was prepared the title compound as yellow oil, MS (ESI+): m/z=286.1 ([M+H]+).

후처리

  1. customat rt
  2. customat −70° C.

출처 및 근거

ORD 기록
ord-9b55fd442b5543129a0136d6f4e36a3a
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765730B2

연결된 노트

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