Propargyl alcohol → 3-[3-(3-Hydroxy-prop-1-ynyl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one

반응식

Br[C:2]1[CH:3]=[C:4]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[O:11])[CH:5]=[CH:6][CH:7]=1.[CH2:26]([OH:29])[C:27]#[CH:28]>>[OH:29][CH2:26][C:27]#[C:28][C:2]1[CH:3]=[C:4]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[O:11])[CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 7859Propargyl alcohol

HCID 67015516HCID 67015516, 화합물

생성물 1

HCID 666689683-[3-(3-Hydroxy-prop-1-ynyl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one

실험 절차

In analogy to example 85, step 1, from 3-(3-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one (example 98, step 5) and 2-propyn-1-ol was prepared the title compound as a white foam, MS (ESI+): m/z=370.18 ([M+H]+).

출처 및 근거

ORD 기록: ord-bf9a3332c68e43f59bf063877b0c6088
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08765730B2

반응 노트

불러오는 중…