Phosphorus oxychloride → 4,6-Dichloro-2-(2-methoxyphenyl)quinoline

반응식

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19])[CH:6]=[C:5]2O.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=2)[N:8]=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[CH:6]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 178489314HCID 178489314, 화합물

생성물 1

HCID 672852334,6-Dichloro-2-(2-methoxyphenyl)quinoline

실험 절차

Prepared according to procedure S using 6-chloro-2-(2-methoxyphenyl)quinolin-4-ol (550.6 mg, 1.93 mmol) and POCl3 (3.5 mL, 37.5 mmol) to afford 4,6-dichloro-2-(2-methoxyphenyl)quinoline. Mass Spectrum (ESI) m/e=304.0 (M+1).

후처리

customPrepared

출처 및 근거

ORD 기록: ord-eb42c37bfbe2444d9639260ca1288268
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08765940B2

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