Hydrazine hydrate (1:1) → HCID 178424063, 화합물
반응식
O.[NH2:2]N.C[N:5](/[CH:7]=[N:8]/[C:9](=O)[C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[C:12]([I:17])[CH:11]=1)C>C(O)(=O)C>[I:17][C:12]1[CH:11]=[C:10]([C:9]2[NH:8][CH:7]=[N:5][N:2]=2)[CH:15]=[CH:14][C:13]=1[CH3:16]참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
Hydrazine monohydrate (0.30 g, 6.0 mmol) was added to a stirred solution of (E)-N-((dimethylamino)methylene)-3-iodo-4-methylbenzamide (preparation 48b, 1.20 g, 3.8 mmol) in acetic acid (6 mL) and the mixture was stirred and heated to 90° C. After 2 hours, the mixture was concentrated in vacuo and water and 2N aqueous sodium hydroxide solution were added to the residue. The solid that formed was filtered, washed with water and dried in vacuo to give the title compound (0.98 g, 91%) as a solid.
후처리
- concentrationthe mixture was concentrated in vacuo and water and 2N aqueous sodium hydroxide solution
- additionwere added to the residue
- customThe solid that formed
- filtrationwas filtered
- washwashed with water
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-0be44e35d1214139b6b9b12cd86b53f8
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08772288B2
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