Hydrogen Peroxide → 2-Amino-4-bromo-6-fluorobenzoic acid

HRID 1619329노트

반응식

HRID 1619329 반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[O:12])C(=O)[NH:8]2)=[C:4]([F:13])[CH:3]=1.[OH:14]O>[OH-].[Na+]>[NH2:8][C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]([F:13])[C:5]=1[C:6]([OH:12])=[O:14]

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 672585381312454-85-5

생성물 1

HCID 672576072-Amino-4-bromo-6-fluorobenzoic acid

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

To a solution of 6-bromo-4-fluoroindoline-2,3-dione (7.4 g, 31.8 mmol) in 1 M NaOH (100 mL) was added 38% H2O2 (13 mL) dropwise. The resulting solution was stirred at rt for 2 h. The mixture was filtered and the filtrate was acidified using hydrochloric acid (2 N) till pH became around 2. The precipitate was formed and filtered, washed with water, dried under vacuum to give 2.8 g of the desired product. MS (ESI): 232, 234 (MH−).

후처리

  1. filtrationThe mixture was filtered
  2. customThe precipitate was formed
  3. filtrationfiltered
  4. washwashed with water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-f322590bfeb841a2a8db703f119164dd
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772301B2

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