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Hydrochloric Acid → 2-(4-(6-(4-(3-Isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol

HRID 1619439
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HRID 1619439 반응식
CC1(C)[O:7][CH2:6][CH:5]([C:8]2[CH:37]=[CH:36][C:11]([O:12][C:13]3[N:18]=[CH:17][N:16]=[C:15]([N:19]4[CH2:24][CH2:23][CH:22]([C:25]5[O:29][N:28]=[C:27]([CH:30]([CH3:32])[CH3:31])[N:26]=5)[CH2:21][CH2:20]4)[C:14]=3[N+:33]([O-:35])=[O:34])=[CH:10][CH:9]=2)[CH2:4][O:3]1.Cl>CC(C)=O>[CH:30]([C:27]1[N:26]=[C:25]([CH:22]2[CH2:21][CH2:20][N:19]([C:15]3[N:16]=[CH:17][N:18]=[C:13]([O:12][C:11]4[CH:36]=[CH:37][C:8]([CH:5]([CH2:6][OH:7])[CH2:4][OH:3])=[CH:9][CH:10]=4)[C:14]=3[N+:33]([O-:35])=[O:34])[CH2:24][CH2:23]2)[O:29][N:28]=1)([CH3:32])[CH3:31]
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참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 675155835-(1-(6-(4-(2,2-Dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

생성물 1

HCID 675166662-(4-(6-(4-(3-Isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol수율 5.4%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
27 °C

실험 절차

To a solution of 5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole (500 mg, 0.0095 moles) in acetone (10 ml) was added conc. HCl (3 ml) and the reaction mixture was stirred for 4 hours at 27° C. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The organic extract was successively washed with water & brine, dried over sodium sulfate and evaporated under reduced pressure to yield 250 mg product as yellow solid.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. extractionThe organic extract
  4. washwas successively washed with water & brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-2b149ae611a24626a9b7690305d5aaa4
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08772302B2

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