홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Acetic Acid → (+/-)-{3-Chloro-6-[(4-fluoro-benzenesulfonyl)-methyl-amino]-5,6,7,8-tetrahydro-2,4b-diaza-fluoren-9-yl}-acetic acid

HRID 1619491
노트
인쇄 미리보기

반응식

HRID 1619491 반응식
C[O:2][C:3](=[O:31])[CH2:4][C:5]1[C:17]2[CH:16]=[N:15][C:14]([Cl:18])=[CH:13][C:12]=2[N:11]2[C:6]=1[CH2:7][CH2:8][CH:9]([N:19]([S:21]([C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)(=[O:23])=[O:22])[CH3:20])[CH2:10]2.O.[Li+].[OH-].CC(O)=O>C1COCC1>[Cl:18][C:14]1[N:15]=[CH:16][C:17]2[C:5]([CH2:4][C:3]([OH:31])=[O:2])=[C:6]3[N:11]([C:12]=2[CH:13]=1)[CH2:10][CH:9]([N:19]([S:21]([C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)(=[O:23])=[O:22])[CH3:20])[CH2:8][CH2:7]3
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 59471421(+/-)-{3-Chloro-6-[(4-fluoro-benzenesulfonyl)-methyl-amino]-5,6,7,8-tetrahydro-2,4b-diaza-fluoren-9-yl}-acetic acid methyl ester

생성물 1

HCID 59471435(+/-)-{3-Chloro-6-[(4-fluoro-benzenesulfonyl)-methyl-amino]-5,6,7,8-tetrahydro-2,4b-diaza-fluoren-9-yl}-acetic acid수율 51.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4 mg of (±)-{3-chloro-6-[(4-fluoro-benzenesulfonyl)-methyl-amino]-5,6,7,8-tetrahydro-2,4b-diaza-fluoren-9-yl}-acetic acid methyl ester in 0.2 mL of THF was added 0.1 mL of water, followed by 0.02 mL of 1 N aq. LiOH solution. After stirring for 1 h at room temperature, 0.05 mL of AcOH was added. The reaction mixture was the dried with a jet flow of nitrogen. The residue was suspended in 0.3 mL of EtOAc and filtered through silica gel. The filtrate was concentrated to give 2 mg of the title compound as a white solid. MS (ESI): 452.1 (M+1).

후처리

  1. customdried with a jet flow of nitrogen
  2. filtrationfiltered through silica gel
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-93df32f5e2fd4be992be5d355084d75c
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08772312B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트