Hydrochloric Acid → HCID 67607082, 화합물
반응식
C(OC([NH:8][CH:9]([C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=1)[C:10]([O:12][C@@H:13]1[CH:18]2[CH2:19][CH2:20][N:15]([CH2:16][CH2:17]2)[CH2:14]1)=[O:11])=O)(C)(C)C.[ClH:28]>C1COCC1>[ClH:28].[ClH:28].[NH2:8][CH:9]([C:21]1[CH:22]=[CH:23][C:24]([CH3:27])=[CH:25][CH:26]=1)[C:10]([O:12][C@@H:13]1[CH:18]2[CH2:17][CH2:16][N:15]([CH2:20][CH2:19]2)[CH2:14]1)=[O:11]참가 물질
4
실험 절차
To a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-p-tolylacetate (C41) (250 mg, 0.67 mmol) in THF (50 ml), was added 37% hydrogen chloride (1.0 ml, 12.2 mmol), and the reaction was stirred at RT for 15 hours. The solvent was evaporated to obtain (R)-quinuclidin-3-yl 2-amino-2-p-tolylacetate dihydrochloride (232 mg; quantitative yield).