1,4-Dioxane → HCID 178509691, 화합물
반응식
[Cl:1][C:2]1[C:3]([O:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([C:42]#[N:43])[CH:37]=3)=[CH:32][C:31]=2[C:44]2[C:45]([N+:55]([O-:57])=[O:56])=[N:46][N:47](C3CCCCO3)[CH:48]=2)=[CH:4][C:5]([F:28])=[C:6]([S:8]([N:11](CC2C=CC(OC)=CC=2OC)[C:12]2[S:13][CH:14]=[N:15][N:16]=2)(=[O:10])=[O:9])[CH:7]=1.O1CCOCC1>Cl>[Cl:1][C:2]1[C:3]([O:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([C:42]#[N:43])[CH:37]=3)=[CH:32][C:31]=2[C:44]2[C:45]([N+:55]([O-:57])=[O:56])=[N:46][NH:47][CH:48]=2)=[CH:4][C:5]([F:28])=[C:6]([S:8]([NH:11][C:12]2[S:13][CH:14]=[N:15][N:16]=2)(=[O:9])=[O:10])[CH:7]=1참가 물질
4
실험 절차
5-Chloro-4-(3′-cyano-3-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide (Preparation 63, 447 mg, 0.537 mmol) was dissolved in a 4M solution of HCl in 1,4-dioxane (2.7 mL, 10.74 mmol). The reaction mixture was stirred at room temperature for 18 hours and then concentrated in vacuo. The residue was purified by reverse phase chromatography on the ISCO™ system to afford the title compound (204 mg, 64%) as a white solid.