Tetrahydrofuran → 7-Hydroxychromanone

HRID 1620022

반응식

HRID 1620022 반응식
O[C:2]1[C:3](=[O:12])[O:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.C1C[O:16]CC1>[OH-].[Pd+2].[OH-]>[OH:16][C:7]1[CH:6]=[C:5]2[C:10]([CH2:11][CH2:2][C:3](=[O:12])[O:4]2)=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 8028TetrahydrofuranHCID 136503-Hydroxycoumarin

생성물 1

HCID 2981307-Hydroxychromanone

시약·촉매·용매 1

HCID 9942167Palladium hydroxide촉매

실험 절차

A solution of hydroxycoumarin (2.0 g, TCI) in anhydrous THF (50 ml) was added with 10% palladium hydroxide/activated carbon (1.0 g, WAKO), and stirred at room temperature for 2 hours under hydrogen atmosphere. The atmosphere was replaced with nitrogen gas, and then the insoluble matters were removed by filtration through Celite. The solvent was evaporated under reduced pressure to obtain the title compound (2.0 g).

후처리

  1. customthe insoluble matters were removed by filtration through Celite
  2. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-42b5a6e743ec43ad98e4c4167e7422da
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772327B2

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