Trifluoroacetic acid → HCID 68616622, 화합물

HRID 1620060노트

반응식

HRID 1620060 반응식
C(O)(C(F)(F)F)=O.C(OC(=O)[NH:14][C:15]1[CH:16]=[N:17][CH:18]=[C:19]([C:21]2[O:22][C:23]([CH3:26])=[CH:24][CH:25]=2)[CH:20]=1)(C)(C)C>C(Cl)(Cl)Cl>[CH3:26][C:23]1[O:22][C:21]([C:19]2[CH:20]=[C:15]([NH2:14])[CH:16]=[N:17][CH:18]=2)=[CH:25][CH:24]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 89546857HCID 89546857, 화합물

생성물 1

HCID 68616622HCID 68616622, 화합물수율 118.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

TFA (1 ml) was added to a chloroform solution (2 ml) containing tert-butyl(5-(5-methylfuran-2-yl)pyridin-3-yl)carbamate (61 mg) obtained in the 1st step, stirring at room temperature for 2 hours. The solvent was distilled away under reduced pressure, the obtained residue was dissolved in chloroform, and the resultant was washed with water and a saturated aqueous sodium hydrogen carbonate solution. Subsequently, the aqueous layers were combined, followed by extraction with chloroform (×2). The organic layers was combined and dried over anhydrous sodium sulfate. The solvent was distilled away from the obtained organic layers under reduced pressure, and a white solid of 5-(5-methylfuran-2-yl)pyridin-3-amine (46 mg) was thus obtained.

후처리

  1. customobtained in the 1st step
  2. distillationThe solvent was distilled away under reduced pressure
  3. dissolutionthe obtained residue was dissolved in chloroform
  4. washthe resultant was washed with water
  5. extractionfollowed by extraction with chloroform (×2)
  6. dry with materialdried over anhydrous sodium sulfate
  7. distillationThe solvent was distilled away from the obtained organic layers under reduced pressure

출처 및 근거

ORD 기록
ord-c57bd9764d5340459d7bed388b3cc92d
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772320B2

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