Hydrochloric Acid → methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride

HRID 1620377노트

반응식

HRID 1620377 반응식
C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[ClH:21].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67056335methyl(S)-3-tert-butoxycarbonylamino-2-piperidin-1-ylpropanoate

생성물 1

HCID 67494635methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

A solution of 750 mg (2.6 mmol) of methyl(S)-3-tert-butoxycarbonylamino-2-piperidin-1-ylpropanoate in 6 ml of methanol and 6 ml of isopropanolic hydrochloric acid, having a concentration of 5-6N, is stirred at 40° C. for 18 h. After concentration under vacuum, the residue is taken up in ethyl acetate, filtered and dried under vacuum. 670 mg (98%) of methyl(S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride are obtained in the form of a white solid.

후처리

  1. concentrationAfter concentration under vacuum
  2. filtrationfiltered
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-ffd2b19576874ea497829ff151111215
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772478B2

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