Hydrochloric Acid → methyl(S)-3-amino-2-morpholin-4-ylpropanoate hydrochloride
반응식
C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:21]>CO.C(O)(C)C>[ClH:21].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12]참가 물질
5
반응 조건
- 온도
- 40 °C
실험 절차
A solution of 1.4 g (5 mmol) of methyl(S)-3-tert-butoxycarbonylamino-2-morpholin-4-ylpropanoate in 20 ml of methanol and 10 ml of a solution of hydrochloric acid having a 5-6N concentration in isopropanol is stirred at 40° C. for 20 h and then evaporated to dryness. 1.3 g (96%) of methyl(S)-3-amino-2-morpholin-4-ylpropanoate hydrochloride are obtained in the form of a solid.
후처리
- customevaporated to dryness
출처 및 근거
- ORD 기록
- ord-ceae3ab955bb427a8ed948687938eb6c
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08772478B2
반응 노트
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