Ethyl 4-oxocyclohexanecarboxylate → Cyclohexanecarboxylic acid, 4-(hydroxyimino)-, ethyl ester

HRID 1620558노트

반응식

HRID 1620558 반응식
Cl.[OH:2][NH2:3].C([O-])(=O)C.[Na+].O=[C:10]1[CH2:15][CH2:14][CH:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][CH2:11]1>O>[OH:2][N:3]=[C:10]1[CH2:15][CH2:14][CH:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][CH2:11]1

참가 물질

5

반응물 3

HCID 317638Ethyl 4-oxocyclohexanecarboxylateHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 11593553Cyclohexanecarboxylic acid, 4-(hydroxyimino)-, ethyl ester수율 100%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of hydroxyamine hydrochloride (15.3 g) and sodium acetate (24.1 g) in water (58.8 mL) was added dropwise ethyl 4-oxocyclohexanecarboxylate (25.0 g) over 20 min. The reaction mixture was stirred at room temperature overnight, and extracted with tert-butyl methyl ether. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (27.2 g).

후처리

  1. extractionextracted with tert-butyl methyl ether
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-81e6a70862f74c03ae8608fd9d89f527
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772277B2

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