Potassium hydroxy sulfite → 4-{[5-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

HRID 1620886노트

반응식

HRID 1620886 반응식
[OH:1]OS([O-])=O.[K+].[C:7]([O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:26])[NH:18][C:19]2[S:20][C:21]([S:24][CH3:25])=[CH:22][N:23]=2)=[CH:13][CH:12]=1)(=[O:9])[CH3:8]>C(Cl)(Cl)Cl>[C:7]([O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17](=[O:26])[NH:18][C:19]2[S:20][C:21]([S:24]([CH3:25])=[O:1])=[CH:22][N:23]=2)=[CH:15][CH:16]=1)(=[O:9])[CH3:8]

참가 물질

4

반응물 2

HCID 23707502Potassium hydroxy sulfiteHCID 575718204-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

생성물 1

HCID 569693934-{[5-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Using the Oxone® procedure as described in section 1.5.1.7 for the synthesis of compound (I), 515 (0.841 g, 2.73 mmol) gives crude 7. The crude product is stirred with chloroform (50 mL) and the suspension is filtered. The pad is washed once with chloroform and air dried to give pure 7 (0.35 g) as a white solid.

후처리

  1. customgives crude 7
  2. filtrationthe suspension is filtered
  3. washThe pad is washed once with chloroform and air
  4. customdried

출처 및 근거

ORD 기록
ord-7e3ee9d730574924bdaf720001ab6ccb
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772502B2

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