Benzaldehyde → HCID 11807110, 화합물

HRID 1621158노트

반응식

HRID 1621158 반응식
[CH:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:9]/[N:10]=[C:11](\[CH3:20])/[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O>Cl.O1CCOCC1>[CH3:20][C:11]1[N+:10]([O-:9])=[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[O:8][C:12]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

5

반응물 2

HCID 240BenzaldehydeHCID 95660631-Phenyl-1,2-propanedione-2-oxime

생성물 1

HCID 11807110HCID 11807110, 화합물수율 51.7%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of benzaldehyde (325 mg, 311 μL, 3.06 mmol) in HCl (4M in dioxane, 10 mL was added (E)-2-(hydroxyimino)-1-phenylpropan-1-one (500 mg, 3.06 mmol) at 0-5° C. The ice bath was removed and the mixture was stirred at RT for 24 h. All volatiles were removed and the residue was dissolved in HCl (4M in dioxane, 10 mL). The reaction mixture was stirred at RT for 6 h and concentrated. The obtained suspension was filtered, washed with diethyl ether and dried in vacuo to give the product as colorless solid (398 mg, 1.58 mmol, 51.7%).

후처리

  1. customThe ice bath was removed
  2. customAll volatiles were removed
  3. dissolutionthe residue was dissolved in HCl (4M in dioxane, 10 mL)
  4. stirringThe reaction mixture was stirred at RT for 6 h
  5. concentrationconcentrated
  6. filtrationThe obtained suspension was filtered
  7. washwashed with diethyl ether
  8. customdried in vacuo

출처 및 근거

ORD 기록
ord-bfeeaac0ee914a47a3590a8951145700
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772510B2

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