N-bromobutanimide → 1-[4-(5-Bromo-2,3-dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanone

반응식

[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH:2]1[CH:10]1[CH2:15][CH2:14][N:13]([C:16](=[O:21])[C:17]([F:20])([F:19])[F:18])[CH2:12][CH2:11]1.[Br:22]N1C(=O)CCC1=O>>[Br:22][C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH:2]([CH:10]3[CH2:15][CH2:14][N:13]([C:16](=[O:21])[C:17]([F:19])([F:18])[F:20])[CH2:12][CH2:11]3)[CH2:3][C:4]=2[CH:9]=1

참가 물질

반응물 2

HCID 67184N-bromobutanimide

HCID 866748861-[4-(2,3-Dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanone

생성물 1

HCID 866748871-[4-(5-Bromo-2,3-dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanone

실험 절차

The title compound is prepared from 1-[4-(2,3-dihydro-benzofuran-2-yl)-piperidin-1-yl]-2,2,2-trifluoro-ethanone and N-bromo-succinimide following a procedure analogous to that described for Intermediate 1. LC (method 2): tR=1.47 min; Mass spectrum (ESI+): m/z=378 [M+H]+.

출처 및 근거

ORD 기록: ord-699cc57ba0504d6a830ffbb4ea8d1847
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08778926B2

반응 노트

불러오는 중…