Imidazole → 3-(4-((Tert-butyl(dimethyl)silyl)oxy)phenyl)pyridin-2-amine

HRID 1622741

반응식

HRID 1622741 반응식
[NH2:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:15]([Si:19]([CH3:22])([CH3:21])Cl)([CH3:18])([CH3:17])[CH3:16].N1C=CN=C1.O>CN(C=O)C>[Si:19]([O:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]2[C:2]([NH2:1])=[N:3][CH:4]=[CH:5][CH:6]=2)=[CH:9][CH:10]=1)([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:22])[CH3:21]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 962WaterHCID 28928tert-Butyldimethylsilyl chlorideHCID 667484774-(2-Aminopyridin-3-yl)phenol

생성물 1

HCID 667477073-(4-((Tert-butyl(dimethyl)silyl)oxy)phenyl)pyridin-2-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4-(2-aminopyridin-3-yl)phenol (19.8 g), tert-butyldimethylchlorosilane (21.8 mL) and 1H-imidazol (8.69 g) in DMF (200 mL) was stirred at room temperature for 20 hr. To the mixture was added water, and the resulting precipitate was collected by filtration, and then washed with water to give the title compound (30.5 g) as a white solid.

후처리

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with water

출처 및 근거

ORD 기록
ord-4fbeb80586f945ee99656b49ed57d9e2
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08778934B2

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