Hydrochloric Acid → (4-Bromo-3-methylphenyl)hydrazine hydrochloride

HRID 16231

반응식

HRID 16231 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[CH3:9].[N:10]([O-])=O.[Na+].[ClH:14]>>[ClH:14].[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][NH2:10])=[CH:4][C:3]=1[CH3:9]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 233594-Bromo-3-methylanilineHCID 23668193Sodium Nitrite

생성물 1

HCID 16495351(4-Bromo-3-methylphenyl)hydrazine hydrochloride

반응 조건

온도
0 °C

실험 절차

4-Bromo-3-methylaniline (10.2 g) was suspended in 6N HCl (85 mL) and cooled to 0° C. A solution of sodium nitrite (4 g in 40 mL H2O) was added over 10 min. The reaction was stirred for 15 min at 0° C. followed by the addition of stannous chloride dihydrate (36 g in 25 mL 12N HCl.) The reaction was stirred for 2 hr at 0° C. The reaction was filtered and the filter cake washed with cold H2O to afford 4-bromo-3-methylphenylhydrazine hydrochloride (Cmpd 9a, 20 g) as a tan solid.

후처리

  1. stirringwas stirred for 2 hr at 0° C
  2. filtrationThe reaction was filtered
  3. washthe filter cake washed with cold H2O

출처 및 근거

ORD 기록
ord-f46b2edaba374d1191254b7edf33b72d
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737154B2

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