Sodium Hydroxide → (4-Methoxy-3-methylpyridin-2-yl)methanol
반응식
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH3:14])[CH:9]=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C1(C)C=CC=CC=1>[OH:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH3:14])[CH:9]=[CH:8][N:7]=1참가 물질
4
실험 절차
15.8 g of 2-acetoxymethyl-3-methyl-4-methoxy-pyridine was added dropwise to a 25% aqueous solution of sodium hydroxide, and the mixture was allowed to react for one hour at room temperature. Subsequently, the reaction liquid was diluted with toluene, and then the toluene phase was washed with water, dried over anhydrous magnesium sulfate, and then concentrated, to obtain 5.7 g of 2-hydroxymethyl-3-methyl-4-methoxy-pyridine as an oily matter.
후처리
- customto react for one hour at room temperature
- customSubsequently, the reaction liquid
- washthe toluene phase was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-ce669b66d5a641eea14f7f2c28c79a05
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08778975B2
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