Sodium Hydroxide → 2-Hydroxymethyl-3-methyl-4-propoxy-pyridine

HRID 1623580노트

반응식

HRID 1623580 반응식
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH3:16])[CH:9]=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C1(C)C=CC=CC=1>[OH:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH3:16])[CH:9]=[CH:8][N:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 684689472-Acetoxymethyl-3-methyl-4-propoxy-pyridine

생성물 1

HCID 140971152-Hydroxymethyl-3-methyl-4-propoxy-pyridine수율 48.7%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

27.8 g of 2-acetoxymethyl-3-methyl-4-propoxy-pyridine was added dropwise into a 25% aqueous solution of sodium hydroxide, and the mixture was allowed to react for one hour at room temperature. Subsequently, the reaction liquid was diluted with toluene, and then the toluene phase was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 11.0 g of 2-hydroxymethyl-3-methyl-4-propoxy-pyridine as an oily matter.

후처리

  1. customto react for one hour at room temperature
  2. customSubsequently, the reaction liquid
  3. washthe toluene phase was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-a41668ad33484ba3acc5aa1d60f20f7e
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08778975B2

반응 노트

불러오는 중…