Sodium Hydroxide → 4-Butoxy-3-methyl-2-pyridinemethanol

HRID 1623583노트

반응식

HRID 1623583 반응식
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH:9]=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C1(C)C=CC=CC=1>[OH:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH:9]=[CH:8][N:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 68469816HCID 68469816, 화합물

생성물 1

HCID 684683474-Butoxy-3-methyl-2-pyridinemethanol수율 75.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

13.4 g of 2-acetoxymethyl-3-methyl-4-butoxy-pyridine was added dropwise to a 25% aqueous solution of sodium hydroxide, and the mixture was allowed to react for one hour at room temperature. The mixture was diluted with toluene, and then the toluene phase was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 8.3 g of 2-hydroxymethyl-3-methyl-4-butoxy-pyridine as an oily matter.

후처리

  1. customto react for one hour at room temperature
  2. washthe toluene phase was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-34f3a2f9b7204100ae38ffa22b5dcef7
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08778975B2

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