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1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 86668199, 화합물

HRID 1623670
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HRID 1623670 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[NH2:19][C:20]1[CH:21]=[C:22]([CH2:26][C:27]([O:29][CH3:30])=[O:28])[CH:23]=[CH:24][CH:25]=1.CCN=C=NCCCN(C)C.CCN(C(C)C)C(C)C>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([C:7]([NH:19][C:20]2[CH:21]=[C:22]([CH2:26][C:27]([O:29][CH3:30])=[O:28])[CH:23]=[CH:24][CH:25]=2)=[O:9])[CH:10]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

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HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 81531DiisopropylethylamineHCID 33011592-(Benzyloxy)-5-chlorobenzoic acidHCID 13054266Methyl 3-aminophenylacetate

생성물 1

HCID 86668199HCID 86668199, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane
용매

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온도
60 °C

실험 절차

A mixture of 5-chloro-2-[(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 45; 50 mg, 0.19 mmol), methyl (3-aminophenyl)acetate (may be prepared as described in Description 44; 48 mg, 0.29 mmol), EDAC (56 mg, 0.29 mmol), and dichloromethane (3 ml) was heated in the microwave at 60° C. for 40 minutes. DIPEA (53 μl, 0.3 mmol) was added and the mixture was heated at 60° C. in the microwave for another 20 minutes. The reaction mixture was purified by SCX cartridge, eluting with methanol. The fractions were combined and evaporated to give the title compound as an off-white solid. 35 mg.

후처리

  1. temperaturethe mixture was heated at 60° C. in the microwave for another 20 minutes
  2. customThe reaction mixture was purified by SCX cartridge
  3. washeluting with methanol
  4. customevaporated

출처 및 근거

ORD 기록
ord-53b93fc6fb1e4471837822d1f11d4c2c
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08778939B2

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