Lithium Hydroxide → HCID 67108246, 화합물

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[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:26]=[CH:25][C:24]([C:27]3[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=3)=[CH:23][C:11]=2[C:12]([O:14]CC2C=CC(F)=CC=2)=[O:13])=[CH:4][CH:3]=1.[Li+].[OH-]>O1CCCC1.O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:26]=[CH:25][C:24]([C:27]3[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=3)=[CH:23][C:11]=2[C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

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실험 절차

(4-Fluorophenyl)methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(1-methyl-1H-pyrazol-4-yl)benzoate (may be prepared as described in Description 120; 360 mg, 0.83 mmol) was dissolved in tetrahydrofuran (20 ml) and water (5 ml). Then LiOH (99 mg, 4.14 mmol) was added. The resultant mixture was stirred at room temperature for 16 hours. The solvent was removed. The residue was dissolved in water (20 ml). The solution was acidified by 1N HCl to pH<5. The precipitate was filtered, washed with ether, and dried in vacuo to yield the title compound as a white solid. 260 mg.