Dimethylformamide → HCID 24803885, 화합물

HRID 1624978노트

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HRID 1624978 반응식
[O:1]=[C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([C:12]([OH:14])=O)[C:6]=2[CH:5]=[CH:4][NH:3]1.[C:15]12([CH2:25][NH2:26])[CH2:24][CH:19]3[CH2:20][CH:21]([CH2:23][CH:17]([CH2:18]3)[CH2:16]1)[CH2:22]2.Cl.CN(C)CCCN=C=NCC.ON1C2C=CC=CC=2N=N1.C(N(CC)CC)C.CN(C)C=O>>[C:15]12([CH2:25][NH:26][C:12]([C:7]3[C:6]4[CH:5]=[CH:4][NH:3][C:2](=[O:1])[C:11]=4[CH:10]=[CH:9][CH:8]=3)=[O:14])[CH2:22][CH:21]3[CH2:20][CH:19]([CH2:18][CH:17]([CH2:23]3)[CH2:16]1)[CH2:24]2

참가 물질

7

반응물 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 86625Tricyclo(3.3.1.13,7)dec-1-ylmethylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 401520381-Oxo-1,2-dihydroisoquinoline-5-carboxylic acid

생성물 1

HCID 24803885HCID 24803885, 화합물

실험 절차

A mixture of 1,2-dihydro-1-oxoisoquinoline-5-carboxylic acid (0.107 g, 0.000566 mol), 1-adamantanemethylamine (0.120 mL, 0.000679 mol), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (0.141 g, 0.000735 mol), 1-hydroxybenzotriazole (0.099 g, 0.00074 mol) and triethylamine (0.12 mL, 0.00085 mol) in N,N-dimethylformamide (2 mL, 0.02 mol) was stirred at room temperature for 18 hours. The mixture was poured onto water (100 ml) and extracted with ethyl acetate (3×100 ml). The combined extracts were dried over sodium sulfate and reduced in vacuo to afford the title compound.

후처리

  1. additionThe mixture was poured onto water (100 ml)
  2. extractionextracted with ethyl acetate (3×100 ml)
  3. dry with materialThe combined extracts were dried over sodium sulfate

출처 및 근거

ORD 기록
ord-d92496f1d33e48a38aa3775b9ad1a812
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08779144B2

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