Trifluoroacetic acid → 2-[2-hydroxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one

HRID 1625133

반응식

HRID 1625133 반응식
FC(F)(F)C(O)=O.C([O:12][CH2:13][CH:14]([C:25]1[N:34]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:33](=[O:41])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:26]=1)[NH:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]2[C:17]=1[N:18]=[CH:19][NH:20]2)(C)(C)C>ClCCl>[OH:12][CH2:13][CH:14]([C:25]1[N:34]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:33](=[O:41])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:26]=1)[NH:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]2[C:17]=1[N:18]=[CH:19][NH:20]2

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 1784505052-[2-tert-butoxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one

생성물 1

HCID 1785150432-[2-hydroxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Compound 92 was prepared by adding trifluoroacetic acid to a solution of 2-[2-tert-butoxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one in dichloromethane. The reaction was stirred at ambient temperature for 18 hours, then concentrated in vacuo. Purification by LC provided the product as a white solid. MS (ES): m/z 400 (M H), 382, 200, 136. Compound 92 is shown below.

후처리

  1. concentrationconcentrated in vacuo
  2. customPurification by LC

출처 및 근거

ORD 기록
ord-a5b62c916f354d34adf9b20cbef2f4fc
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08779131B2

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