O-(4-Nitrophenyl)hydroxylamine → (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone

HRID 1625192

반응식

HRID 1625192 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10]N)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=[O:28])[CH2:21][C:22](=O)[CH2:23][CH2:24][CH2:25][CH3:26])=[CH:16][CH:15]=1>C(O)(=O)C>[CH2:23]([C:22]1[O:10][C:7]2[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][C:6]=2[C:21]=1[C:20](=[O:28])[C:17]1[CH:18]=[CH:19][C:14]([O:13][CH3:12])=[CH:15][CH:16]=1)[CH2:24][CH2:25][CH3:26]

참가 물질

4

반응물 2

HCID 15562106O-(4-Nitrophenyl)hydroxylamineHCID 445418181-(4-Methoxyphenyl)-heptane-1,3-dione

생성물 1

HCID 22595055(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone수율 70%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
70 °C

실험 절차

O-4-nitrophenylhydroxylamine (100 mg), was suspended in 0.5 ml acetic acid and 1-(4-methoxyphenyl)-heptane-1,3-dione was added. The mixture was stirred at 70° C. for 3 h and then at 100° C. for an additional 14 h. The mixture was cooled to room temperature and the solvent evaporated under vacuum. Yield 70% of 2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran.

후처리

  1. waitat 100° C. for an additional 14 h
  2. temperatureThe mixture was cooled to room temperature
  3. customthe solvent evaporated under vacuum

출처 및 근거

ORD 기록
ord-3c7a7e1806bd48a19f946c7756e4e421
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08779201B2

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