Sodium Hydroxide → AM432 sodium

HRID 1625677노트

반응식

HRID 1625677 반응식
[CH:1]1([C:4]([N:6]([CH2:9][C:10]2[CH:15]=[C:14]([C:16]3[CH:17]=[N:18][C:19]([O:22][CH2:23][CH3:24])=[CH:20][CH:21]=3)[CH:13]=[CH:12][C:11]=2[C:25]2[C:30]([O:31][CH3:32])=[CH:29][CH:28]=[C:27]([CH2:33][C:34]([OH:36])=[O:35])[CH:26]=2)[CH2:7][CH3:8])=[O:5])[CH2:3][CH2:2]1.[OH-].[Na+:38]>C(O)C>[Na+:38].[CH:1]1([C:4]([N:6]([CH2:9][C:10]2[CH:15]=[C:14]([C:16]3[CH:17]=[N:18][C:19]([O:22][CH2:23][CH3:24])=[CH:20][CH:21]=3)[CH:13]=[CH:12][C:11]=2[C:25]2[C:30]([O:31][CH3:32])=[CH:29][CH:28]=[C:27]([CH2:33][C:34]([O-:36])=[O:35])[CH:26]=2)[CH2:7][CH3:8])=[O:5])[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 50901658AM-432

생성물 1

HCID 50901657AM432 sodium

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

[2′-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid (26.0 g, 53.2 mmol) was dissolved in ethanol (180 mL), sodium hydroxide (53.2 mL, 1N aq.) was added and the reaction was stirred at room temperature for 1 hour. The solution was filtered to remove solid impurities then concentrated. The residue was dissolved in water (˜150 mL) then frozen and lyophilized to afford the title compound.

후처리

  1. filtrationThe solution was filtered
  2. customto remove solid impurities
  3. concentrationthen concentrated
  4. dissolutionThe residue was dissolved in water (˜150 mL)
  5. temperaturethen frozen

출처 및 근거

ORD 기록
ord-7a2151900fe24802a73a78c5d42daa99
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785393B2

반응 노트

불러오는 중…