참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Chloroaniline | HCID 7812 | — |
| 반응물 | 5-Amino-4,6-dichloropyrimidine | HCID 79434 | — |
| 용매 | Water ethanol | HCID 19096565 | — |
| 생성물 | 6-Chloro-N4-(4-chlorophenyl)pyrimidine-4,5-diamine | HCID 16726311 | 88% |
반응 단계
5-amino-4,6-dichloropyrimidine (5.0 g, 30.49 mmol) and 4-chloroaniline (5.1 g, 40.0 mmol) were added to the solution of hydrochloric acid (1.3 mL, 15.24 mmol) in EtOH/H2O (8:1 v/v) (100 ml). The resulting reaction mixture was stirred for overnight at 80° C. The resulting mixture was filtered with NaHCO3(aq)/H2O. The collected solid was dried under reduced pressure to obtain the title compound (6.8 g, 88%) as white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08785453B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_07 |
|---|
| ORD ID | ord-d21fcab5b95448b589bb27cca1537fc6 |
|---|
| 출처 메모 | uspto-grants-2014_07 |
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