홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Ethyl Acetate → (S)-tert-butyl 2-chloro-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate

HRID 1626535
노트
인쇄 미리보기

반응식

HRID 1626535 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH2:10][N:9]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:8][C:6]=2[N:7]=1.[CH3:19][CH2:20][N:21](C(C)C)[CH:22]([CH3:24])[CH3:23].CC[O:30]C(C)=O>C(Cl)Cl.C([O-])(O)=O.[Na+]>[Cl:1][C:2]1[N:3]=[C:4]([N:21]2[CH2:20][CH2:19][O:30][CH2:23][C@@H:22]2[CH3:24])[C:5]2[CH2:10][N:9]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:8][C:6]=2[N:7]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 17998715tert-Butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo(3,4-d)pyrimidine-6-carboxylate

생성물 1

HCID 86663148(S)-tert-butyl 2-chloro-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate

시약·촉매·용매 2

HCID 6344Dichloromethane용매2회
HCID 516892
Sodium Bicarbonate
용매

반응 조건

온도
35 °C

실험 절차

To a solution of tert-butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate (1.61 g, 5.54 mmol) and DIPEA (1.1 mL, 6.21 mmol) at room temperature (20° C.) in DCM (10 mL) was added 3-S-methyl morpholine (0.98 g, 9.65 mmol). The reaction mixture was heated to 35° C. and stirred for 24 h. The reaction was diluted with DCM and Sat. NaHCO3. The organic layer was rinsed (brine), dried (anhydrous Na2SO4) and concentrated in vacuo. The desired product was isolated by flash chromatography (silica, 50 g, 0-30% EtOAc in petroleum ether (40-60) over 40 min) as a white solid (1.80 g, 5.07 mmol, 82% yield).

후처리

  1. washThe organic layer was rinsed (brine)
  2. dry with materialdried (anhydrous Na2SO4)
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-25eb95756ade4fbfa3d80a367b8ab526
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08785457B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트