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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6-(piperidin-4-ylmethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

HRID 1626643
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인쇄 미리보기

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HRID 1626643 반응식
[CH:1]1([NH:4][C:5](=[O:43])[NH:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[N:14]=[C:15]([N:36]4[CH2:41][CH2:40][O:39][CH2:38][C@@H:37]4[CH3:42])[C:16]4[CH2:21][N:20]([CH2:22][CH:23]5[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]5)[CH2:19][C:17]=4[N:18]=3)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.Cl.CO>O1CCOCC1>[CH:1]1([NH:4][C:5]([NH:6][C:7]2[CH:8]=[CH:9][C:10]([C:13]3[N:14]=[C:15]([N:36]4[CH2:41][CH2:40][O:39][CH2:38][C@@H:37]4[CH3:42])[C:16]4[CH2:21][N:20]([CH2:22][CH:23]5[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]5)[CH2:19][C:17]=4[N:18]=3)=[CH:11][CH:12]=2)=[O:43])[CH2:3][CH2:2]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 66679044(S)-tert-butyl 4-((2-(4-(3-cyclopropylureido)phenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)methyl)piperidine-1-carboxylate

생성물 1

HCID 66679207(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6-(piperidin-4-ylmethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea수율 25%

시약·촉매·용매 1

HCID 31275
1,4-Dioxane
용매

실험 절차

(S)-tert-butyl 4-((2-(4-(3-cyclopropylureido)phenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)methyl)piperidine-1-carboxylate (example 128) (24 mg, 0.04 mmol) was stirred in a solution of 4M HCl in dioxane (1 mL), and methanol (0.5 mL) until analysis by LCMS indicated reaction was complete. Reaction mixture was then purified by TsOH cartridge (loaded in MeOH eluted with 2M methanolic ammonia) to afford an orange brown solid (4.9 mg, 0.009 mmol, 25%).

후처리

  1. customreaction
  2. customReaction mixture
  3. customwas then purified by TsOH cartridge (loaded in MeOH eluted with 2M methanolic ammonia)

출처 및 근거

ORD 기록
ord-c7a6594699b2403787cddc3d11df0a94
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08785457B2

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