4-Acetamidobutyric acid → (S)-N-(4-(2-(4-(3-cyclopropylureido)phenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-4-oxobutyl)acetamide

HRID 1626646

반응식

HRID 1626646 반응식
[C:1]([NH:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=O)(=[O:3])[CH3:2].[CH:11]1([NH:14][C:15]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[N:25]=[C:26]([N:33]4[CH2:38][CH2:37][O:36][CH2:35][C@@H:34]4[CH3:39])[C:27]4[CH2:32][NH:31][CH2:30][C:28]=4[N:29]=3)=[CH:20][CH:19]=2)=[O:16])[CH2:13][CH2:12]1>>[CH:11]1([NH:14][C:15](=[O:16])[NH:17][C:18]2[CH:19]=[CH:20][C:21]([C:24]3[N:25]=[C:26]([N:33]4[CH2:38][CH2:37][O:36][CH2:35][C@@H:34]4[CH3:39])[C:27]4[CH2:32][N:31]([C:8](=[O:10])[CH2:7][CH2:6][CH2:5][NH:4][C:1](=[O:3])[CH3:2])[CH2:30][C:28]=4[N:29]=3)=[CH:22][CH:23]=2)[CH2:13][CH2:12]1

참가 물질

3

반응물 2

HCID 181894-Acetamidobutyric acidHCID 46894114(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

생성물 1

HCID 66679045(S)-N-(4-(2-(4-(3-cyclopropylureido)phenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-4-oxobutyl)acetamide수율 39%

실험 절차

Method as example 127 using 4-acetamidobutanoic acid and (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 3) as starting materials. Purified by Prep HPLC at low pH to afford a white solid (46.5 mg, 0.089 mmol, 39%).

후처리

  1. customPurified by Prep HPLC at low pH

출처 및 근거

ORD 기록
ord-fc5442640481436f99ea0d671f68ad48
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785457B2

연결된 노트

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