Iodine → 5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde
반응식
[F:1][C:2]1[CH:7]=[N:6][C:5]2[NH:8][CH:9]=[CH:10][C:4]=2[C:3]=1[CH:11]=[O:12].[I:13]I.[I-].[Na+].[OH-].[Na+]>CCO.OS([O-])=O.[Na+]>[F:1][C:2]1[CH:7]=[N:6][C:5]2[NH:8][CH:9]=[C:10]([I:13])[C:4]=2[C:3]=1[CH:11]=[O:12]참가 물질
7
반응 조건
- 온도
- 25 °C
실험 절차
To a solution of 5-fluoro-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (2.45 g, 14.93 mmol) in EtOH (20 mL) was added iodine (4.55 g, 17.91 mmol), sodium iodide (2.68 g, 17.91 mmol) and aqueous NaOH (1N, 15 mL). The reaction mixture was stirred for 4 h at 25° C. and diluted with aqueous NaHSO3 (0.1N). An orange precipitate was collected by filtration and dried under vacuum to afford the title compound as a yellow solid (6.54 g, 82%). [M+H] calc'd for C8H4FIN2O, 291; found, 291.5.
후처리
- filtrationAn orange precipitate was collected by filtration
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-a73d16bc99b24174b6f9b3f72e5ae241
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08785429B2
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