Methylhydrazine → HCID 86664828, 화합물

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[NH:10][N:9]=2)[CH:5]=[CH:4][N:3]=1.[CH3:14]NN>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 6061Methylhydrazine

HCID 178507310HCID 178507310, 화합물3회

생성물 1

HCID 86664828HCID 86664828, 화합물수율 89%

실험 절차

This title intermediate was prepared starting from 18.B (3.10 g, 17.3 mmol) according the procedure described above for conversion of 18.B to 18.C, except that methylhydrazine (3.5 equiv.) was used. The crude product was purified by flash chromatography on silica gel using 0-8% MeOH/CH2Cl2 for elution to provide 23.A (3.44 g mg, 89%) as a brown solid.

후처리

customThe crude product was purified by flash chromatography on silica gel using 0-8% MeOH/CH2Cl2 for elution

출처 및 근거

ORD 기록: ord-18456180be1243f0a8af25b68f19576c
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08785468B2

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