2,6-Dichloropyrazine → 2-Chloro-6-(indanone-5-oxy)-pyrazine

HRID 16287

반응식

HRID 16287 반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[OH:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[C:15](=[O:19])[CH2:14][CH2:13]2>CCOC(C)=O>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:9][C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[C:15](=[O:19])[CH2:14][CH2:13]3)[N:3]=1

참가 물질

4

반응물 2

HCID 785042,6-DichloropyrazineHCID 2331475-Hydroxy-1-indanone

생성물 1

HCID 593434572-Chloro-6-(indanone-5-oxy)-pyrazine수율 100%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Using Method DD with 2,6-dichloropyrazine (200 mg, 1.34 mmol) and 5-hydroxyindanone (219 mg, 1.49 mmol), and crystallisation in AcOEt, the title compound was obtained (350 mg). Yield: 100%. 1H NMR (250 MHz, DMSO-d6) δ 2.67 (t, 2H, H3, J=5.9 Hz), 3.13 (t, 2H, H2, J=5.5 Hz), 7.31 (dd, 1H, Harom 6, Jm=1.9 Hz, Jo=8.3 Hz), 7.47 (d, 1H, Harom 4, J=1.3 Hz), 7.73 (d, 1H, Harom 7, J=8.3 Hz), 8.59 (s, 1H, HPz 5), 8.64 (s, 1H, HPz 3). m/z: 261.0 [(M+H)+, calcd for C13H9ClN2O2 260.0].

출처 및 근거

ORD 기록
ord-e265725f75314f558d749618500cb5f6
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737152B2

연결된 노트

불러오는 중…