Hydrochloric Acid → Methyl 3-methylazetidine-3-carboxylate hydrochloride

HRID 1629710노트

반응식

HRID 1629710 반응식
[CH3:1][O:2][C:3]([C:5]1([CH3:16])[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4].[ClH:17]>C(Cl)Cl>[ClH:17].[CH3:1][O:2][C:3]([C:5]1([CH3:16])[CH2:8][NH:7][CH2:6]1)=[O:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 574158901-Tert-butyl 3-methyl 3-methylazetidine-1,3-dicarboxylate

생성물 1

HCID 67329141Methyl 3-methylazetidine-3-carboxylate hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of INT 13 (1.66 g, 7.24 mmol) in CH2Cl2 was added HCl (2.0 M in Et2O, 36.2 mL, 72.4 mmol). The reaction mixture was stirred at room temperature for 20 hours. The mixture was concentrated to afford INT 14.

후처리

  1. concentrationThe mixture was concentrated
  2. customto afford INT 14

출처 및 근거

ORD 기록
ord-76244b54abf84904a71c0776b0fe435c
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791100B2

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