HCID 16069467, 화합물 → 5-Chloronaphthalene-2-carbonitrile
반응식
ClC(Cl)(Cl)C(O[C:6]1[CH:11]=C[C:9](C#N)=[CH:8][C:7]=1CC=C)=O.[Cl-:19].N1C=CC=CC=1CN1C=C[N+]([CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=2)=C1>ClCCCl.Cl[Cu]>[Cl:19][C:6]1[CH:11]=[CH:32][CH:33]=[C:38]2[C:7]=1[CH:8]=[CH:9][C:36]([C:35]#[N:34])=[CH:37]2참가 물질
5
실험 절차
A solution of INT 26 (1.01 g, 3.6 mmol) in degassed 1,2-dichloroethane (20 mL) containing CuCl (14.3 mg, 0.144 mmol) and 1,3-bis(pyridin-2-ylmethyl)-1H-imidazol-3-ium chloride (41.3 mg, 0.144 mmol, prepared according to: Journal of Organometallic Chemistry (2001), Vol. 617-618, 546-560.) was irradiated in the microwave for 2 hours at 200° C. and concentrated. The residue was purified by flash chromatography on silica gel (cyclohexane/EtOAc) to give INT 27.
후처리
- customwas irradiated in the microwave for 2 hours at 200° C.
- concentrationconcentrated
- customThe residue was purified by flash chromatography on silica gel (cyclohexane/EtOAc)
- customto give INT 27
출처 및 근거
- ORD 기록
- ord-6958c70fe42f4eb1bce963ffec09a4b4
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08791100B2
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