Hydrochloric Acid → Methyl 3-amino-3-(4-butoxyphenyl)butanoate

HRID 1629799노트

반응식

HRID 1629799 반응식
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([NH:19]S(C(C)(C)C)=O)([CH3:18])[CH2:13][C:14]([O:16][CH3:17])=[O:15])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].Cl>CO>[NH2:19][C:12]([C:9]1[CH:8]=[CH:7][C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[CH:11][CH:10]=1)([CH3:18])[CH2:13][C:14]([O:16][CH3:17])=[O:15]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86685892Methyl 3-(4-butoxyphenyl)-3-((tert-butylsulfinyl)amino)butanoate

생성물 1

HCID 86685893Methyl 3-amino-3-(4-butoxyphenyl)butanoate수율 97.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of Intermediate 107B (1 g, 2.71 mmol) in MeOH (6 mL) was added 4 N HCl (3.38 mL, 13.53 mmol). The reaction was stirred at rt for 4 h. The reaction mixture was concentrated in vacuo and diluted with EtOAc. The organic layer was washed with saturated NaHCO3, dried over MgSO4, filtered and concentrated to yield the desired product (700 mg, 97%) as a yellow oil. 1H NMR (500 MHz, CDCl3) δ 7.38 (d, J=8.80 Hz, 2H), 6.86 (d, J=8.80 Hz, 2H), 3.95 (t, J=6.46 Hz, 2H), 3.59 (s, 3H), 1.73-1.80 (m, 2H), 1.53 (s, 2H), 1.45-1.52 (m, 2H), 1.19 (s, 3H), 0.98 (t, J=7.29 Hz, 3H).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with EtOAc
  3. washThe organic layer was washed with saturated NaHCO3
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2b81051b0a564aafba2f3fefd6f04a51
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791091B2

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