Sodium Hydroxide → 4-(1,1-Dioxo-1,2-thiazolidin-2-yl)-3-methylbenzoic acid

HRID 1629841노트

반응식

HRID 1629841 반응식
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][C:8]=1[CH3:17].[OH-].[Na+]>C(O)C>[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[CH3:17]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 67048536Methyl 4-(1,1-dioxo-isothiazolidin-2-yl)-3-methyl-benzoate

생성물 1

HCID 246888114-(1,1-Dioxo-1,2-thiazolidin-2-yl)-3-methylbenzoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

170 mg (0.63 mmol) methyl 4-(1,1-dioxo-isothiazolidin-2-yl)-3-methyl-benzoate are stirred in 2 ml of ethanol at ambient temperature for 3 hours with 0.6 ml of 2-molar sodium hydroxide solution. Then the reaction solution is evaporated down i. vac., combined with water and 0.6 ml 2-molar hydrochloric acid and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate, evaporated down i. vac. and the residue is further reacted without any more purification.

후처리

  1. customThen the reaction solution is evaporated down i
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organic phases are dried over sodium sulphate
  4. customevaporated down i
  5. customand the residue is further reacted without any more purification

출처 및 근거

ORD 기록
ord-30a07968824445cfa6852d9430cfd051
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791103B2

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