Hydrochloric Acid → 1-(5-chloro-1H-benzimidazol-2-yl)-1-phenyl-methylamine
반응식
C([NH:4][CH:5]([C:12]1[NH:16][C:15]2[CH:17]=[CH:18][C:19]([Cl:21])=[CH:20][C:14]=2[N:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=O)C.Cl>C(O)C>[Cl:21][C:19]1[CH:18]=[CH:17][C:15]2[NH:16][C:12]([CH:5]([NH2:4])[C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)=[N:13][C:14]=2[CH:20]=1참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
1.34 g (4.47 mmol) N-acetyl-1-(5-chloro-1H-benzimidazol-2-yl)-1-phenyl-methylamine in 9 ml of ethanol are combined with 18 ml of conc. hydrochloric acid and heated to 50° C. for 2 days. The reaction mixture is evaporated down i. vac. and twice taken up in ethanol and evaporated down again.
후처리
- customThe reaction mixture is evaporated down i
- customevaporated down again
출처 및 근거
- ORD 기록
- ord-a1bdef8b3d214163a9ac758baea076c9
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08791103B2
반응 노트
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