Hydrochloric Acid → 2-(3-Bromophenyl)propan-2-ol

HRID 1630374노트

반응식

HRID 1630374 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[CH3:11][Mg]I.C(OCC)C.C(OCC)C.Cl>O>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([OH:10])([CH3:11])[CH3:9])[CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 165023'-BromoacetophenoneHCID 178467823HCID 178467823, 화합물

생성물 1

HCID 150723832-(3-Bromophenyl)propan-2-ol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a nitrogen atmosphere with cooling with ice, 5.29 mL of 3′-bromoacetophenone was added to 25 mL of 2 M methylmagnesium iodide/diethyl ether solution and 100 mL of diethyl ether, and stirred for 20 minutes. Water and 2 N hydrochloric acid were added to the reaction liquid, extracted with ethyl acetate, washed with aqueous saturated sodium hydrogencarbonate solution and saturated saline water, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain crude 2-(3-bromophenyl)propan-2-ol.

후처리

  1. extractionextracted with ethyl acetate
  2. washwashed with aqueous saturated sodium hydrogencarbonate solution and saturated saline water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. customThe solvent was evaporated away under reduced pressure

출처 및 근거

ORD 기록
ord-d99b0a7bcc9a48ecb7ec7af0b217a2ce
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791125B2

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