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Hydroxyamine hydrochloride → methyl 1-(3-chloropyridin-2-yl)-3-[(hydroxyimino)methyl]-1H-pyrazole-5-carboxylate

HRID 1630669
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HRID 1630669 반응식
[Cl:1][C:2]1[C:3]([N:8]2[C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][C:10]([CH:17]=O)=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.Cl.[NH2:20][OH:21].C([O-])(=O)C.[Na+]>C(O)C.O.C(OC)(C)(C)C>[Cl:1][C:2]1[C:3]([N:8]2[C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][C:10]([CH:17]=[N:20][OH:21])=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 86661390HCID 86661390, 화합물

생성물 1

HCID 136407523methyl 1-(3-chloropyridin-2-yl)-3-[(hydroxyimino)methyl]-1H-pyrazole-5-carboxylate

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매
HCID 15413
tert-Butyl methyl ether
용매

실험 절차

Methyl 1-(3-chloropyridin-2-yl)-3-formyl-1H-pyrazole-5-carboxylate (0.99 g), hydroxylamine hydrochloride (0.39 g) and sodium acetate (0.61 g) were stirred at RT in a mixture of 5 ml of ethanol and 3 ml of water for 30 min. The mixture was diluted with methyl tert-butyl ether, washed with saturated sodium chloride solution and dried over sodium sulphate. Distillative removal of the solvent gave the desired target product.

후처리

  1. washwashed with saturated sodium chloride solution
  2. dry with materialdried over sodium sulphate
  3. customDistillative removal of the solvent
  4. customgave the desired target product

출처 및 근거

ORD 기록
ord-82c8cfae78df4abc95c5f024c597ce50
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08791139B2

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