tert-Butyl acrylate → tert-butyl N-[3-(4-hydroxyphenyl)propyl]-beta-alaninate

HRID 1631191노트

반응식

HRID 1631191 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[C:12]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])(=[O:15])[CH:13]=[CH2:14]>CO>[OH:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][CH2:3][CH2:2][NH:1][CH2:14][CH2:13][C:12]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 15458tert-Butyl acrylateHCID 4574248HCID 4574248, 화합물

생성물 1

HCID 23121488tert-butyl N-[3-(4-hydroxyphenyl)propyl]-beta-alaninate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a methanol solution (25 mL) of 4-(3-aminopropyl)phenol (1.83 g), tert-butyl acrylate (1.7 mL) was added dropwise thereto at room temperature, followed by stirring at room temperature overnight. The reaction mixture was concentrated. The residue was purified by silica gel column chromatography (ethyl acetate→ethyl acetate:methanol=3:1) to give the title compound (1.55 g) having the following physical properties.

후처리

  1. customat room temperature
  2. concentrationThe reaction mixture was concentrated
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate→ethyl acetate:methanol=3:1)

출처 및 근거

ORD 기록
ord-074bd78e66724358a075bc1cfdd5e079
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791159B2

반응 노트

불러오는 중…