Hydrochloric Acid → 1-(Trifluoromethyl)cyclopropanamine hydrochloride
반응식
[F:1][C:2]([F:15])([F:14])[C:3]1([NH:6]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1.[ClH:16]>>[ClH:16].[F:1][C:2]([F:15])([F:14])[C:3]1([NH2:6])[CH2:5][CH2:4]1참가 물질
3
실험 절차
A solution of tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (0.3 g, 1.3 mmol) in HCl (4 N dioxane, 6.7 mL, 27 mmol) was stirred at ambient temperature overnight. The reaction was then concentrated to yield the crude product as white solid, which was used directly in the next step assuming quantitative yield.
후처리
- concentrationThe reaction was then concentrated
출처 및 근거
- ORD 기록
- ord-4b2961abd96b4c80aa3a7da09cbbd5fc
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08791123B2
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