Water → HCID 136352181, 화합물

HRID 1631569노트

반응식

[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([O-:17])=O)[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Na+].O.C([NH:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(C)C.O1C[CH2:33][CH2:32][CH2:31]1>>[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([NH:23][C:24]3[CH:25]=[CH:26][CH:27]=[C:28]([CH:32]([CH3:33])[CH3:31])[CH:29]=3)=[O:17])[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

참가 물질

반응물 4

HCID 962Water

HCID 8028Tetrahydrofuran

HCID 13032N-Isopropylaniline

HCID 136041844Sodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

생성물 1

HCID 136352181HCID 136352181, 화합물

실험 절차

The product is prepared according to the procedure described in Example 19, using 653 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and using a mixture of 10 ml of water and 2 ml of tetrahydrofuran in place of the methanol and 270 mg of isopropylaniline in place of the 3-(tert-butyl)aniline. 235 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yl)phenyl]acetamide are obtained in the form of a white solid, the characteristics of which are the following:

후처리

customThe product is prepared

출처 및 근거

ORD 기록: ord-bed39c29b4ed4b9785b6e9d8df794478
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08791255B2

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