Imidazo-[1,2-a]-quinoline-2-methanol → Imidazo[1,2-a]quinoline-2-carbaldehyde

HRID 1632197노트

반응식

HRID 1632197 반응식
[CH:1]1[N:5]2[C:6]3[C:11]([CH:12]=[CH:13][C:4]2=[N:3][C:2]=1[CH2:14][OH:15])=[CH:10][CH:9]=[CH:8][CH:7]=3>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[CH:1]1[N:5]2[C:6]3[C:11]([CH:12]=[CH:13][C:4]2=[N:3][C:2]=1[CH:14]=[O:15])=[CH:10][CH:9]=[CH:8][CH:7]=3

참가 물질

4

반응물 1

HCID 13770452Imidazo-[1,2-a]-quinoline-2-methanol

생성물 1

HCID 13770453Imidazo[1,2-a]quinoline-2-carbaldehyde수율 81.8%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

A mixture of 4.2 g of imidazo-[1,2-a]-quinoline-2-methanol, 16.0 g of manganese dioxide and 11 ml of chloroform was refluxed for 4 hours and was then cooled overnight. The mixture was filtered through cellulose powder and the filter was washed with chloroform. The filtrate was evaporated to dryness under reduced pressure and the residue was triturated with diethyl ether to obtain 3.4 g of imidazo-[1,2-a]-quinoline-2-carboxaldehyde in the form of needles melting at 184°-185° C. after crystallization from an ether-chloroform mixture.

후처리

  1. temperaturewas refluxed for 4 hours
  2. temperaturewas then cooled overnight
  3. filtrationThe mixture was filtered through cellulose powder
  4. washthe filter was washed with chloroform
  5. customThe filtrate was evaporated to dryness under reduced pressure
  6. customthe residue was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-909ca12906e74fae83a02a78eec2e5dd
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04474784

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