1,2-Dimethylindole → 4-(1,2-Dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid

HRID 1632888

반응식

HRID 1632888 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[CH3:11].[Cl:12][C:13]1=[C:14]([Cl:20])[C:15]([O:17][C:18]1=[O:19])=[O:16]>C(Cl)CCl>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:15](=[O:16])[C:14]([Cl:20])=[C:13]([Cl:12])[C:18]([OH:19])=[O:17])=[C:3]1[CH3:11]

참가 물질

4

반응물 2

HCID 134081,2-DimethylindoleHCID 70728Dichloromaleic anhydride

생성물 1

HCID 2362024-(1,2-Dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid수율 91.5%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

A mixture of 10.0 g (0.07 mole) of 1,2-dimethylindole, 12.0 g (0.07 mole) of dichloromaleic anhydride and 200 ml of ethylene dichloride was stirred at ambient temperature for approximately eighteen hours. The solid present in the reaction mixture was collected by filtration. After drying at 60° C. in vacuo there was obtained 20.0 g of 4-(1,2-dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid (Formula VIII: R=R1 =CH3 ; Y=H) as a pale blue solid which melted over the range 150° to 153° C. Infrared spectral analysis showed a maximum at 1712 (C=0; s) cm-1.

후처리

  1. filtrationThe solid present in the reaction mixture was collected by filtration
  2. customAfter drying at 60° C. in vacuo

출처 및 근거

ORD 기록
ord-ca53f09abe594f30aa46f740eb300ec3
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04477676

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