Hydrazine hydrate (1:1) → Endralazine

HRID 1633036노트

반응식

HRID 1633036 반응식
[C:1]([N:9]1[CH2:19][CH2:18][C:12]2[N:13]=[N:14][C:15](Cl)=[CH:16][C:11]=2[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:21][NH2:22]>>[C:1]([N:9]1[CH2:19][CH2:18][C:12]2[N:13]=[N:14][C:15]([NH:21][NH2:22])=[CH:16][C:11]=2[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 12582765HCID 12582765, 화합물

생성물 1

HCID 47608Endralazine

실험 절차

A suspension of 21.6 g of 6-benzoyl-3-chloro-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine in 80 cc of hydrazine hydrate is boiled at reflux at an oil bath temperature of 110° for 1 hour. After a reaction time of approximately 15 minutes the material dissolves completely. The crude title compound resulting after cooling the mixture, is washed with a small amount of absolute ethanol and dissolved in 60 cc of dimethyl formamide. 60 cc of absolute ethanol are added to the solution, whereupon the title compound crystallizes.

후처리

  1. temperatureat reflux at an oil bath temperature of 110° for 1 hour
  2. dissolutionAfter a reaction time of approximately 15 minutes the material dissolves completely

출처 및 근거

ORD 기록
ord-42ad74e2cb9f491db7485b14e38898e0
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04478837

반응 노트

불러오는 중…