Hydrochloric Acid → N-nitroso-N-(5-methoxycarbonylpentyl)-aniline

HRID 1633151노트

반응식

HRID 1633151 반응식
[N:1]([O-:3])=O.[Na+].[CH3:5][O:6][C:7]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:8].Cl>O>[N:1]([N:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:7]([O:6][CH3:5])=[O:8])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 20441676Methyl 6-(phenylamino)hexanoateHCID 23668193Sodium Nitrite

생성물 1

HCID 13362122N-nitroso-N-(5-methoxycarbonylpentyl)-aniline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 1.4 g of sodium nitrite in 5 ml of water is added dropwise at 0°-10° to a mixture of 4.42 g of N-(5-methoxycarbonylpentyl)-aniline, 2.9 ml of concentrated hydrochloric acid, and ice as needed to maintain the desired temperature. The mixture is then allowed to stir at ambient temperature for 1 hour and is then extracted with ether. The extract is washed with water, dried over magnesium sulfate, and evaporated in vacuo to give N-nitroso-N-(5-methoxycarbonylpentyl)-aniline as an oil.

후처리

  1. temperatureto maintain the desired temperature
  2. extractionis then extracted with ether
  3. washThe extract is washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-13e73071e92d43899593294fa55b015d
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04478842

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